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SARS-CoV-2 genomic diversity and within-host evolution in individuals with persistent infection in the UK: an observational, longitudinal, population-based surveillance study.
Ghafari M. The Lancet Microbe 2025;:https://doi.org/10.1016/j.lanmic.2025.101154.
[This study highlights the heterogeneous nature of within-host SARS-CoV-2 evolution in individuals with persistent infection in the community. A subset of persistent infections with high viral loads underwent accelerated viral evolution or recurrently acquired hallmark mutations found in novel variants. Onward transmission from a persistent infection during the later stages of infection is likely to be rare.]
Freely available online
Age Groups
Adults
Conditions and Lifestyle Factors
Bacterial Diseases
Coronavirus Infections
Settings
Hospital Laboratories
Staff Groups
Biomedical Scientist
Clinical Scientist