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Evaluating the use of the first WHO International Standard for anti-SARS-CoV-2 immunoglobulin to harmonise the readouts between commercial SARS-CoV-2 binding antibody tests: the HARMONY multicentre calibration study.
Semper A. The Lancet Microbe 2026;:https://doi.org/10.1016/j.lanmic.2025.101329.
[These findings provide proof-of-concept evidence that for the biologically important SARS-CoV-2 spike protein, levels of anti-RBD, S1, or spike IgG binding antibodies can successfully be compared across a range of well validated commercial assays with different designs and formats through previous calibration and reporting in standardised units. The BAU/mL values assigned to the two secondary standards enable their use as alternative calibration reagents.]
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Biomedical Scientist
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