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Comprehensive longitudinal profiling identifies differential frequency, epitope specificity, and effector function of CD8+ T-cells across COVID-19 disease severities.
Hernandez SPA. eBioMedicine 2026;:https://doi.org/10.1016/j.ebiom.2026.106310.
[CD8+ T-cells are crucial for controlling and resolving SARS-CoV-2 infection, yet their epitope specificity and relationship to COVID-19 disease severity remain incompletely understood. These findings delineate the epitope-specific frequency, function, and persistence of antigen-specific T-cell populations during SARS-CoV-2 infection, highlighting how differential activation, rather than magnitude alone, shapes immune outcomes across disease severities and other viral infections.]
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Age Groups
Adults
Conditions and Lifestyle Factors
Coronavirus Infections
Settings
Hospital Laboratories
Staff Groups
Biomedical Scientist
Clinical Scientist